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                                                                                                                                    团队名称:细胞应激与损伤修复团队

                                                                                                                                     

                                                                                                                                    团队负责人:蒋凡

                                                                                                                                     

                                                                                                                                    成员:娄海燕张斌王建丽姜晶晶王婧婧郭晓笋

                                                                                                                                    主要研究方向:

                                                                                                                                    1)血管生物学;细胞的应激与保护机制

                                                                                                                                    2神经药理学及心脑血管药理学

                                                                                                                                     

                                                                                                                                    主持的课题:

                                                                                                                                    1. 国家自然科学基金面上项目,81770469rDNA转录机器在腹主动脉瘤发病机制中的作用,2018/01-2021/1255万元,在研

                                                                                                                                    2. 国家自然科学基金重大研究计划(培育项目),91539102,死亡受体与血管炎症稳态,2016/01- 2018/1278万元,在研

                                                                                                                                    3.国家自然科学基金面上项目,31471087,剪切力对内皮细胞自噬反应的影响及意义,2015/01-2018/1280万元,在研

                                                                                                                                    4.国家自然科学基金面上项目,81271269,脑出血病人血浆中 microRNA 水平的变化及其对血管细胞再生修复功能的影响,2013/01-2016/1249万元,已结题

                                                                                                                                    5.国家自然科学基金面上项目,81070164NOX4介导的氧化还原信号通路促进毛细血管新生及抑制内皮细胞凋亡的生物学机制,2011/01 -2013/1230万元,已结题

                                                                                                                                    6973项目子课题,2010CB732605,心脑血管易损斑块的高分辨成像识别与风险评估预警体系重大问题的基础研究(子课题名称:三维血流流场成像与斑块破裂的力学机制)2010/01-2014/12440万元,已结题

                                                                                                                                    7.国家自然科学基金面上项目 青兰属黄酮类化合物基于Nrf2-ARE信号通路对脑缺血再灌注损伤的保护作用及机制。2013.1-2016.12 70 结题

                                                                                                                                     8.国家自然科学基金青年基金项目 青兰属黄酮调控Nrf2/ARE信号通路在帕金森病模型中的神经保护作用及机制。2013.1-2015.12 23 结题

                                                                                                                                     9.山东省自然科学基金,ZR2018MH043TREM2调控小胶质细胞M1/M2表型转化及在帕金森病中的作用,2018/03-2021/0615万,在研

                                                                                                                                     10.山东省重点研发计划,2017GSF18187TFEB调控自噬溶酶体通路在脑缺血再灌注损伤中的作用及海藻糖的保护作用研究,2017/01-2018/1210万,在研,主持;

                                                                                                                                     11.山东省科技攻关计划 Nrf2-ARE信号通路介导的自噬调节对缺血性脑卒中的保护作用研究及药物干预。 2014.10-2016.10 10 结题

                                                                                                                                     12.教育部留学归国启动基金 α-Synuclein磷酸化修饰对TH PP2A活性的影响 2012-2014 3.5 结题

                                                                                                                                     

                                                                                                                                    近五年发表的论文:

                                                                                                                                     1. Feng Yan, Yuan Wang, Xiao Wu, Hitesh M. Peshavariya, Gregory J. Dusting, Mei Zhang, and Fan Jiang. Nox4 and redox signaling mediate TGF-beta-induced endothelial cell apoptosis and phenotypic switch. Cell Death & Disease, 2014 Jan 23;5:e1010.

                                                                                                                                     

                                                                                                                                     2. Fan Jiang*, Guei-Sheung Liu, Gregory J. Dusting, Elsa C. Chan*. NADPH oxidase-dependent redox signaling in TGF-b-mediated fibrotic responses. Redox Biol. 2014 Jan 20;2:267-272.

                                                                                                                                     

                                                                                                                                     3. Fan Jiang, Jianmin Yang, Yongtao Zhang, Mei Dong, Shuangxi Wang, Qunye Zhang, Fang Fang Liu, Kai Zhang and Cheng Zhang. Angiotensin-converting enzyme 2 and angiotensin 1–7: novel therapeutic targets. Nature Reviews Cardiology, 2014 Jul;11(7):413-26.

                                                                                                                                     

                                                                                                                                     4. Pengxiang Li, Qunye Zhang, Xiao Wu, Xinjian Yang, Yun Zhang, Youxiang Li*, Fan Jiang*. Circulating microRNAs serve as novel biological markers for intracranial aneurysms. J Am Heart Assoc, 2014; 3(5): e000972.

                                                                                                                                     

                                                                                                                                     5. Elsa C. Chan, Gregory J. Dusting, Guei-Sheung Liu, Fan Jiang. Redox mechanisms of the beneficial effects of heme oxygenase in hypertension. Journal of Hypertension, 2014 Jul;32(7):1379-86.

                                                                                                                                     

                                                                                                                                     6. Wen Cheng, Yuxia Zhao, Shuangxi Wang, Fan Jiang*. Tumor necrosis factor-related apoptosis-inducing ligand in vascular inflammation and atherosclerosis: a protector or culprit? Vascular Pharmacology, 2014 Dec;63(3):135-144.

                                                                                                                                     

                                                                                                                                     7. Zhang Yongtao, Bi Xiaolei, Jiang Fan. Cytotoxin-induced NADPH oxides activation: roles in regulation of cell death. Arch Toxicol. 2015 Jul;89(7):991-1006.

                                                                                                                                     

                                                                                                                                     8. 张勇涛, 蒋凡. 生理性和病理性心肌肥厚的信号传导机制. 中华心血管病杂志 Chin J Cardiol, 20153月,43(3): 277-280.

                                                                                                                                     

                                                                                                                                     9. Liu J, Bi X, Chen T, Zhang Q, Wang SX, Chiu JJ, Liu GS, Zhang Y, Bu P*, Jiang F*. Shear stress regulates endothelial cell autophagy via redox regulation and Sirt1 expression. Cell Death Dis. 2015 Jul 16; 6: e1827.

                                                                                                                                     

                                                                                                                                     10. Zhang Y, Fang Liu F, Bi X, Wang S, Wu X, Jiang F*. The antioxidant compound tert-butylhydroquinone activates Akt in myocardium, suppresses apoptosis and ameliorates pressure overload-induced cardiac dysfunction. Sci Rep. 2015 Aug 11; 5: 13005.

                                                                                                                                     

                                                                                                                                     11. Cheng W, Liu F, Wang Z, Zhang Y, Zhao YX*, Zhang Q, Jiang F*. Soluble TRAIL Concentration in Serum Is Elevated in People with Hypercholesterolemia. PLoS One, 2015 Dec 3; 10(12): e0144015.

                                                                                                                                     

                                                                                                                                     12. Sun M, Ji J, Guo X, Liu W, Wang Y, Ma S, Hu W, Wang J, Jiang F. Early adventitial activation characterized by NADPH oxidase expression and neovascularization in an aortic transplantation model. Exp Mol Pathol. 2016 Dec 3; 100(1): 67-73.

                                                                                                                                     

                                                                                                                                     13. Jiang F*. Search for magic patches that heal the broken heart. Clin Exp Pharmacol Physiol. 2016 Mar; 43(3):290-3.

                                                                                                                                     

                                                                                                                                     14. Guei-Sheung Liu*, Hitesh Peshavariya, Masayoshi Higuchi, Elsa C. Chan, Gregory J. Dusting, Fan Jiang*. Pharmacological priming of adipose-derived stem cells for paracrine VEGF production with deferoxamine. J Tissue Eng Regen Med. 2016 Mar; 10(3):E167-76.

                                                                                                                                     

                                                                                                                                     15. Yuan Wang, Feng Yan, Qing Ye, Xiao Wu & Fan Jiang*. PTP1B inhibitor promotes endothelial cell motility by activating the DOCK180/Rac1 pathway. Sci Rep. 2016 Apr 7; 6:24111.

                                                                                                                                     

                                                                                                                                     16. Fan Jiang*. Autophagy in vascular endothelial cells. Clin Exp Pharmacol Physiol. 2016 Nov; 43(11):1021-1028.

                                                                                                                                     

                                                                                                                                     17. Ye Q, Pang S, Zhang W, Guo X, Wang J, Zhang Y, Liu Y, Wu X, Jiang F*. Therapeutic Targeting of RNA Polymerase I With the Small-Molecule CX-5461 for Prevention of Arterial Injury-Induced Neointimal Hyperplasia. Arterioscler Thromb Vasc Biol. 2017 Mar;37(3): 476-484.

                                                                                                                                     

                                                                                                                                     18. Hao P#, Jiang F, Cheng J, Ma L, Zhang Y, Zhao Y*. Traditional Chinese Medicine for Cardiovascular Disease: Evidence and Potential Mechanisms. J Am Coll Cardiol. 2017 Jun 20;69(24):2952-2966.

                                                                                                                                     

                                                                                                                                     19. Xiaotong Guo#, Mengyao Sun, Chaochao Dai, Xun Zhang, Qihui Yin, Xiao Wu, Fan Jiang*, Jianli Wang*. Macrophage-stimulated microRNA expression in mural cells promotes transplantation-induced neointima formation. Oncotarget. 2017 May 2;8(18):30100-30111.

                                                                                                                                     

                                                                                                                                     20. Yuan Wang#, Feng Yan#, Wenjing Zhang, Shu Pang and Fan Jiang*. Inhibiting protein tyrosine phosphatase 1B to improve regenerative functions of endothelial cells. J Cardiovasc Pharmacol. 2018 Feb;71(2):59-64.

                                                                                                                                     

                                                                                                                                     21. 魏亚萍, 王媛, 郭晓笋*, 蒋凡*. 细胞内的氧化还原感受器蛋白与氧化还原信号转导. 中国病理生理杂志. 2018; 34(1):183-187.

                                                                                                                                     

                                                                                                                                     22. Jianli Wang, Yuan Wang, Jingjing Wang, Xiaosun Guo, Elsa C. Chan, Fan Jiang. Adventitial activation in the pathogenesis of injury-induced arterial remodeling: potential implications in transplant vasculopathy. Am J Pathol. 2018 Apr;188(4):838-845.

                                                                                                                                     

                                                                                                                                     23. Dai C#, Sun M#, Wang F, Zhu J, Wei Y, Guo X, Ma S, Dong B, Wang G, Jiang F* and Wang J*. The selective RNA polymerase I inhibitor CX-5461 mitigates neointimal remodeling in a modified model of rat aortic transplantation. Transplantation. 2018 Oct;102(10):1674-1683.

                                                                                                                                     

                                                                                                                                     24. Xiaolei Bi#, Qing Ye#, Daoyuan Li, Qisheng Peng, Zhe Wang, Xiao Wu, Yun Zhang, Qunye Zhang*, Fan Jiang*. Inhibition of nucleolar stress response by Sirt1: a potential mechanism of acetylation-independent regulation of p53 accumulation. Aging Cell. 2019 Jan 8: e12900.

                                                                                                                                     

                                                                                                                                     25. Yaping Wei, Mei Meng, Zhenyu Tian, Fubo Xie, Qihui Yin, Chaochao Dai, Jingjing Wang, Qunye Zhang, Yu Liu, Chang Liu, Feng Yan, Fan Jiang, Xiaosun Guo. Pharmacological preconditioning with the cellular stress inducer thapsigargin protects against experimental sepsis. Pharmacological Research. 2018 Dec 21;141:114-122.

                                                                                                                                     

                                                                                                                                     26. Ren M, Guo Y, Wei X, Yan S, Qin Y, Zhang X, Jiang F, Lou H (通讯作者). TREM2 overexpression attenuates neuroinflammation and protects dopaminergic neurons in experimental models of Parkinson's disease. Exp Neurol. 2018; 302:205-213.

                                                                                                                                     

                                                                                                                                     27. Ren M, Han M, Wei X, Guo Y, Shi H, Zhang X, Perez RG*, Lou H*. FTY720 Attenuates 6-OHDA-Associated Dopaminergic Degeneration in Cellular and Mouse Parkinsonian Models. Neurochem Res. 2017, 42(2):686-696. (共同通讯作者)

                                                                                                                                     

                                                                                                                                     28. Shi H, Jing X, Wei X, Perez RG, Ren M, Zhang X, Lou H (通讯作者). S-allyl cysteine activates the Nrf2-dependent antioxidant response and protects neurons against ischemic injury in vitro and in vivo. J Neurochem. 2015, 133(2):298-308

                                                                                                                                     

                                                                                                                                     29. Jing X, Wei X, Ren M, Wang L, Zhang X, Lou H (通讯作者). Neuroprotective Effects of Tanshinone I Against 6-OHDA-Induced Oxidative Stress in Cellular and Mouse Model of Parkinson's Disease Through Upregulating Nrf2. Neurochem Res. 2016, 41(4):779-86

                                                                                                                                     

                                                                                                                                     30. Jing X, Shi H, Zhang C, Ren M, Han M, Wei X, Zhang X, Lou H (通讯作者). Dimethyl fumarate attenuates 6-OHDA-induced neurotoxicity in SH-SY5Y cells and in animal model of Parkinson's disease by enhancing Nrf2 activity. Neuroscience. 2015,286:131-40.

                                                                                                                                     

                                                                                                                                     
                                                                                                                                     
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